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Magic™ Antibody Discovery - Human Mesothelin / MSLN (296-580) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP0656F)

Datasheet
This membrane protein is Human Mesothelin / MSLN (296-580). It has been tested in SDS-PAGE, ELISA, HPLC, FACS. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Mesothelin / MSLN
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 58.6 kDa. The protein migrates as 66-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Glu 296 - Gly 580 (Accession # AAH09272.1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, HPLC, FACS
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <0.1 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
    >90% as determined by SEC-HPLC.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Mesothelin / MSLN
  • Full Name
  • mesothelin
  • Introduction
  • This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
  • Alternative Names
  • MPF; SMRP; mesothelin; CAK1 antigen; megakaryocyte potentiating factor; pre-pro-megakaryocyte-potentiating factor; soluble MPF mesothelin related protein

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